Research Interests

• Methodological Innovation for Personalized Nutrition: Applying the idea of “n-of-1” clinical trials or “single-patient” studies in the field of personalized nutrition research, aiming to identify individual responses to a given intervention in a controlled trial, which provides a great opportunity to assess the personalization potential of different diets, nutrients, or nutrition supplements. Integrating Bayesian analysis into the statistical analysis for “n-of-1” trials, to solve the problem that the widely used frequentist approach (e.g., use of p values or confidence intervals) is no longer applicable in the statistical analysis for “single-patient” or within an individual.
• Precision Nutrition for Life-long Health: Integrating novel study designs (e.g., nutritional n-of-1 clinical trial) and cutting-edge wearable devices (e.g., continuous glucose monitoring, wrist-worn triaxial accelerometer) to explore individual’ personalized response to identical diets in pregnant women, apparently healthy adults, or elderly participants. Discovering the mechanisms behind the personalized response to identical interventions using multi-omics technologies (e.g., gut microbiome, host genome, proteome, metabolome) and identifying novel biomarkers or potential interventional targets.

Selected Publications

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• Fu Y#, Gou W#, Wu P#, Lai Y#, Liang X, Zhang K, Shuai M, Tang J, Miao Z, Chen J, Yuan J, Zhao B, Yang Y, Liu X, Hu Y, Pan A*, Pan XF*, Zheng JS*. Landscape of the gut mycobiome dynamics during pregnancy and its relationship with host metabolism and pregnancy health. Gut. 2024.




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• Ma S, Xu F, Fu Y*, Zheng JS*. Genetic mapping of plasma proteome on brain structure.J Genet Genomics. 2024.




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• Jia J#, Shuai M#, Yan W, Tang Q, Wang B, Tang W, Wang P, Zhang T, Yang S, Zhang Y, Liu Q, Fu Y*, Cai W*, Zheng JS. Conserved covarying gut microbial network in preterm infants and childhood growth during the first 5 years of life: a prospective cohort study.Am J Clin Nutr. 2023.




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• Shuai M#, Fu Y#, Zhong HL#, Gou W, Jiang Z, Liang Y, Miao Z, Xu JJ, Huynh T, Wahlqvist ML, Chen YM*, Zheng JS*. Mapping the human gut mycobiome in middle-aged and elderly adults: multiomics insights and implications for host metabolic health.Gut. 2022.




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• Liang X#, Fu Y#, Lu S, Shuai M, Miao Z, Gou W, Shen L, Liang Y, Xu F, Tian Y, Wang J, Zhang K, Xiao C, Jiang Z, Shi MQ, Wu YY, Wang XH, Hu WS, Zheng JS*. Continuous glucose monitoring-derived glycemic metrics and adverse pregnancy outcomes among women with gestational diabetes: a prospective cohort study. Lancet Reg Health West Pac. 2023.




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• Tian Y, Gou W, Ma Y, Shuai M, Liang X, Fu Y*, Zheng JS*. The Short-Term Variation of Human Gut Mycobiome in Response to Dietary Intervention of Different Macronutrient Distributions. Nutrients. 2023.




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• Yu D, Xie L, Chen W, Qin J, Zhang J, Lei M, Wang Y, Tang H, Xue S, Liang X, Miao Z, Xiao C, Shang M, Lu J, Di H*, Fu Y*. Dynamics of the Gut Bacteria and Fungi Accompanying Low-Carbohydrate Diet-Induced Weight Loss in Overweight and Obese Adults.Front Nutr. 2022.




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• Liang X#, Fu Y#, Cao WT, Wang Z, Zhang K, Jiang Z, Jia X, Liu CY, Lin HR, Zhong H, Miao Z, Gou W, Shuai M, Huang Y, Chen S, Zhang B, Chen YM*, Zheng JS*. Gut microbiome, cognitive function and brain structure: a multi-omics integration analysis.Transl Neurodegener. 2022.




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• Fu Y#, Xu F, Jiang L, Miao Z, Liang X, Yang J, Larsson SC, Zheng JS*. Circulating vitamin C concentration and risk of cancers: a Mendelian randomization study.BMC Med. 2021.




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• Xu F#, Fu Y#, Sun TY, Jiang Z, Miao Z, Shuai M, Gou W, Ling CW, Yang J, Wang J, Chen YM*, Zheng JS*. The interplay between host genetics and the gut microbiome reveals common and distinct microbiome features for complex human diseases. Microbiome. 2020.




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• Fu Y#, Gou WL#, Hu WS#, Mao YY, Tian YY, Liang XX, Guan YH, Huang T, Li KL, Guo XF, Liu HJ, Li D, Zheng JS*. Integration of an interpretable machine learning algorithm to identify early life risk factors of childhood obesity among preterm infants: a prospective birth cohort. BMC Med. 2020.




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• Lu S#, Fu Y#, Wu YY, Mao AF, Xu MY, Zheng GY, Cai FC, Wang XH, Shi MQ, Hu WS*. Mediating Effects of Maternal Blood Triglycerides on the Relationship between Prepregnancy Body Mass Index and Fetal Macrosomia. J Pediatr. 2020.




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• Fu Y, Liu X, Zhou B, Jiang AC, Chai LY*. An updated review of worldwide levels of docosahexaenoic and arachidonic acid in human breast milk by region. Public Health Nutrition. 2016.




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• Fu Y, Li GP, Zhang XH, Xing GY, Yang LF, Hu XJ, Li D*. Lipid extract from hard-shelled mussel (Mytilus coruscus) improves clinical conditions of patients with rheumatoid arthritis: a randomized controlled trial. Nutrients. 2015.




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• Fu Y, Zheng JS, Yang B, Li D*. Effect of individual omega-3 fatty acids on the risk of prostate cancer: a systematic review and dose-response meta-analysis of prospective cohort studies. Journal of Epidemiology. 2015.




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• Fu Y, Zhang Y, Hu HY, Chen Y, Wang R, Li D*, Liu S*. Design and straightforward synthesis of novel galloyl phytosterols with excellent antioxidant activity. Food Chem. 2014.




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• Fu Y, Hong S, Li D, Liu S*. Novel chemical synthesis of ginkgolic acid (13:0) and evaluation of its tyrosinase inhibitory activity. Journal of Agricultural and Food Chemistry. 2013.




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